Risk of thyroid cancer, brain cancer, and non-Hodgkin?s lymphoma following adult leukemia: a nationwide study.
Blood. 2011 Aug 12;
Authors: Nielsen SF, Bojesen SE, Birgens HS, Nordestgaard BG
Patients with childhood leukemia surviving into adulthood have elevated risk of developing thyroid cancer, brain cancer and non-Hodgkin?s lymphoma; these risks cannot automatically be extrapolated to patients surviving adult leukemia. We tested if survivors of adult leukemia are at increased risk of developing thyroid cancer, brain cancer, and non-Hodgkin?s lymphoma. We included the entire adult Danish population, aged 14 years or above, in a 28 year follow-up period from 1980 through 2007 comprising 6,542,639 individuals; during this period, 18,834 developed adult leukemia, 4,561 developed thyroid cancer, 13,362 developed brain cancer, and 15,967 developed non-Hodgkin?s lymphoma. In nested studies using Cox regression models on individual participant data, we found that, following adult leukemia the multivariate adjusted hazard ratios were 4.9 (95% confidence interval, 2.8-8.5) for thyroid cancer, 1.9 (1.2-3.1) for brain cancer, and 3.3 (2.5-4.4) for non-Hodgkin?s lymphoma. Corresponding hazard ratios following childhood leukemia were 10.4 (0.4-223) for thyroid cancer, 7.2 (2.0-26) for brain cancer, and 6.5 (0.4-110) for non-Hodgkin?s lymphoma. Patients with adult leukemia have excess risk of thyroid cancer, brain cancer, and non-Hodgkin?s lymphoma like patients with childhood leukemia.
PMID: 21841167 [PubMed - as supplied by publisher]
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